Chemistry requires an understanding of molecular structure, knowledge of molecular reactivity, and the creativity to combine them in novel situations. The Path to Synthesis is intended to build a bridge between the two-dimensional and three-dimensional representations in a real-world situation. This website follows the semi-synthesis of Taxol, showing the reaction mechanisms for each step. The conventional, “arrow-pushing” two-dimensional notation is animated and moves synchronously with a modern, “video-game” style three-dimensional representation. Created by Matthew Radcliff, a science filmmaker and animator, with Joseph Fox, from the University of Delaware, and funded by the NSF and the Dreyfus Foundation.