Scientific research conducted around the world has formed a body of evidence documenting that humans have set in motion profound global changes. A multiplicity of innovations will be needed at all scales of society for people to thrive on a human-dominated planet. A more secure future is attainable if individuals and societies are open to new ways of achieving high qualities of life that reduce pressures on planetary systems. A first step toward a more sustainable future is a broader societal realization that humanity has crossed a threshold from being an merely inhabitant of Earth to being its leading architect.